Defisiensi G6PD

Defisiensi G6PD merupakan penyakit dengan gangguan herediter pada aktivitas eritrosit (sel darah merah), di mana terdapat kekurangan enzim glukosa-6-fosfat-dehidrogenase (G6PD). Enzim G6PD ini berperan pada perlindungan eritrosit dari reaksi oksidatif. Karena kurangnya enzim ini, eritrosit jadi lebih mudah mengalami penghancuran (hemolisis). Terjadinya hemolisis ditandai dengan demam yang disertaijaundice (kuning) dan pucat di seluruh tubuh dan mukosa. Urin juga berubah warna menjadi jingga-kecoklatan; ditemukan tanda syok (nadi cepat dan lemah, frekuensi pernapasan meningkat), dan tanda kelelahan umum.

Hemolisis ini dapat dipicu oleh konsumsi obat-obatan. Selain obat-obatan, makanan tertentu juga dapat memicu timbulnya serangan hemolitik pada anak dengan defisiensi G6PD; misalnya kacang fava (fava beans) dan kacang-kacangan tertentu. Berikut ini adalah daftar obat-obatan yang perlu dipertimbangkan pemberiannya pada pasien defisiensi G6PD.

Berisiko sangat tinggi (defisiensi ringan termasuk)	Berisiko tinggi (defisiensi ringan tidak termasuk)	Berisiko jika dikonsumsi dalam dosis tinggi
Arsin Asetilfenilhidrazin Betanaftol Dapson (diafenilsulfon) Dimerkaprol Furazolidon Menadiol-Na-sulfat (vitamin K4 Na-sulfat) Menadion (menafton) Menadion-Na-bisulfit (vitamin K3 Na-bisulfit) Metilen biru Naftalin Na-aldesulfon Na-glukosulfon Niridazol Nitrofurantoin Nitrofurazon Pamakuin Pentakuin Primakuin Probenesid Stibofen Sulfasetamid Sulfadimidin Sulfametoksazol Sulfanilamid Sulfapiridin Sulfasalazin Toluidin biru	Asam asetilsalisilat (aspirin) Asam nalidiksat Asam paraaminosalisilat Asetanilid Doksorubisin Fenasetin Glibenklamid Kloramfenikol Klorokuin Kuinakrin Siprofloksasin (adult only) Sulfafurazol	Aminopirin Antazolin Antipirin Asam askorbat (vitamin C) Asam paraaminobenzoat (PABA) Benzheksol Difenhidramin Dopamin dan L-dopa Fenilbutazon Fenitoin Fitomenadion (vitamin K1) Isoniazid (INH) Klorguanidin Kolkisin Kuinidin Kuinin (kina) Norfloksasin (adult only) Parasetamol Pirimetamin Proguanil Prokainamid Streptomisin Sulfadiazin Sulfaguanidin Sulfamerazin Sulfametoksipiridazin Sulfasitin Sulfisoksazol Triheksifenidil Trimetoprim Tripelenamin

World Health Organization (WHO), mengklasifikasikan varian mutan G6PD berdasarkan pengukuran aktivitas enzim dan ada atau tidaknya anemia hemolitik, kemudian dibagi lagi atas dasar mobilitas elektroforesis dalam setiap varian sebagai berikut :

1. Klas I: varian G6PD yang defisiensi enzimnya sangat berat (aktivitas enzim kurang dari 10% dari normal) dengan anemia hemolitik kronis.

2. Klas II: varian G6PD yang defisiensi enzimnya cukup berat (aktivitas enzim kurang dari 10% dari normal) namun tidak ada anemia hemolitik kronis.

3. Klas III: varian G6PD dengan aktivitas enzimnya antara 10%-60% dari normal dan anemi hemolitik terjadi bila terpapar bahan oksidan atau infeksi.

4. Klas IV: varian G6PD yang tidak memberikan anemia hemolitik atau penurunan aktivitas enzim G6PD

5. Klas V: varian G6PD yang aktivitas enzimnya meningkat.

Varian klas IV dan klas V secara biologis, genetik dan antropologis tidak didapat gejala klinik.

Anemia hemolitik akut akibat induksi obat

Sebagian besar manifestasi varian mutan gen G6PD yang mengakibatkan defisiensi enzim G6PD kurang dari 60% dari normal, terjadi setelah paparan obat atau bahan kimia yang memicu terjadi anemia hemolitik akut. Umumnya, setelah satu sampai tiga hari terpapar bahan bahan tersebut, penderita akan mengalami demam, letargi, kadang disertai gejala gastrointestinal. Hemoglobinuria merupakan tanda cardinal terjadinya hemolisis intravascular ditandai dengan terjadinya urine berwarna merah gelap hingga coklat. Kemudian timbul ikterus dan anemia yang disertai takikardia. Pada beberapa kasus berat dapat terjadi syok hipovolemik. Dapat terjadi komplikasi berupa Acute tubular necrosis pada episode hemolitik, terutama bila terdapat penyakit dasar berupa gangguan hepar seperti hepatitis.

Anemia Hemolisis akut karena infeksi

Infeksi merupakan penyebab paling umum terjadinya hemolisis. Infeksi bakteri dan virus seperti Hepatitis, Salmonella, Escherchia coli, Streptoccus β hemolitikus dan Rickettsia, dapat menyebabkan anemia hemolitik pada penderita defisiensi G6PD dan mekanisme terjadinya hemolisis belum jelas. Salah satu sebab yang dapat menjelaskan hubungan infeksi dengan hemolisis adalah akibat proses fagositosis. Lekosit menghasilkan radikal oksigen aktif selama proses fagositosis yang mengakibatkan kerusakan membran eritrosit. Hemolisis yang terjadi karena dipicu oleh infeksi biasanya ringan.

Hemolisis dapat timbul satu sampai dua hari setelah onset terjadinya infeksi dan dapat menimbulkan anemia ringan. Biasanya terjadi pada pasien dengan klinis pnemoni atau demam tifoid. Infeksi virus hepatitis pada pasien defisiensi G6PD dapat memperparah timbulnya ikterus.

Jumlah dan produksi retikulosit rendah dan hal ini akan pulih setelah infeksi primer dapat disembuhkan

Anemia Hemolitik akut karena Favism

Manifestasi klinik defisiensi enzim G6PD lainnya yang dapat menyebabkan anemia hemolitik adalah anemia hemolitik yang disebabkan konsumsi fava bean, Vicia faba. Penderita favisme selalu defisiensi enzim G6PD namun tidak semua penderita defisiensi G6PD bisa menderita favisme. Diduga terdapat faktor genetik lainnya yang berhubungan dengan metabolisme bahan aktif dari fava bean.

Favisme merupakan salah satu efek hematologi yang paling berat pada penderita defisiensi G6PD. Manifestasi klinis yang timbul dapat lebih hebat dibandingkan anemia hemolisis yang disebabkan oleh obat. Hemolisis dapat timbul beberapa jam hingga beberapa hari setelah konsumsi kacang.

Favisme banyak didapatkan pada anak dibanding pada dewasa. Terutama pada varian mutan gen defisiensi G6PD tipe Mediteranean, varian mutan gen G6PD lainnya yang dapat mengalami favisme adalah tipe G6PD A-. Gejala yang timbul pada anak berupa gelisah hingga letargi beberapa jam setelah terpapar fava bean. Dalam waktu 24 – 48 jam dapat timbul demam disertai mual muntah, nyeri abdomen dan diare. Urine berwarna merah hingga coklat gelap yang dapat berlangsung selama beberapa haril. Ikterus timbul bersama terjadinya urine yang gelap. Anak tampak pucat, terdapat takikardia. Pada beberapa kasus, dapat terjadi syok hipovolemi dengan segera yang dapat berakibat fatal hingga terjadi gagal jantung. Biasanya terdapat pembesaran hepar dan limpa yang ringan.

Adanya kasus maternal favisme pada ibu hamil dilaporkan menyebabkan hemolisis pada bayi penderita defisiensi G6PD yang disusui, bahkan dapat terjadi hydrops fetalis.

Manifestasi non hematologi

Beberapa kasus defisiensi G6PD dilaporkan dapat memberikan manifestasi non hematologi. Dilaporkan bahwa defisiensi G6PD dapat mengakibatkan juvenile cataract pada lensa mata. Bahkan bilateral cataract ditemukan pada anak dengan defisiensi G6PD. Pada penelitian lebih lanjut ditemukan bahwa aktivitas enzim G6PD hanya sebesar 40% dibanding individu normal.

Defisiensi G6PD juga dapat menyebabkan kejang otot, kelelahan pada otot, gangguan kehamilan, katarak dan infeksi yang berulang. Dilaporkan pula bahwa defisiensi aktivitas G6PD pada lekosit dan netrofil dapat menyebabkan defek pada sistem imun yang menyebabkan infeksi berulang dan terbentuknya granuloma pada beberapa kasus. Defisiensi G6PD menunjukkan heterogenitas genetik yang cukup kompleks dan bervariasi dari satu populasi ke populasi lain. Varian mutasi gen G6PD yang berbeda dapat menentukan ringan beratnya gejala klinik serta berbagai akibat lain yang cukup serius dan dapat mengancam kehidupan

Tata Laksana

Defisiensi enzim G6PD yang dapat menyebabkan anemia hemolitik, ikterus maupun manifestasi non hemolitik merupakan kelainan genetik yang diwariskan secara X-linked resesif. Karena itu, kelainan ini tidak dapat disembuhkan. Tata laksana utama kelainan enzim G6PD berupa upaya pencegahan.

Upaya pencegahan hanya dapat dilakukan bila telah diketahui masalah yang harus dihadapi. Untuk itu merupakan hal penting untuk mendapatkan karakteristik gen G6PD dan pola variasi gen G6PD sehingga membantu untuk diagnosis dini dan mempelajari sejauh mana permasalahan defisiensi G6PD ini sebagai etiologi penyebab anemia hemolitik atau gejala klinis yang lain.

Upaya pencegahan dapat dibagi menjadi pencegahan primer, pencegahan sekunder dan pencegahan tersier.

Upaya pencegahan primer

Upaya pencegahan primer termasuk skrining untuk mengetahui frekuensi (angka kejadian) kelainan enzim G6PD di masyarakat yang membantu diagnosis dini karena sebagian besar defisiensi G6PD tidak menunjukkan gejala klinis, sehingga pemahaman mengenai akibat yang mungkin timbul pada penderita defisiensi G6PD yang terpapar bahan oksidan masih belum sepenuhnya dipahami serta disadari yang dapat mengakibatkan diagnosis dini terlewatkan.

Masih termasuk pencegahan primer yaitu dengan memberikan informasi dan pendidikan kepada masyarakat mengenai kelainan enzim G6PD, termasuk berupa konseling genetik pada pasangan resiko tinggi.

Upaya pencegahan sekunder

Upaya pencegahan sekunder berupa pencegahan terpaparnya penderita defisiensi enzim G6PD dengan bahan bahan oksidan yang dapat menimbulkan manifestasi klinis yang merugikan seperti yang terdapat pada tabel III sehingga dapat tercapai sumber daya manusia yang optimal.

Sekali diagnosa defisien enzim G6PD ditegakkan, orang tua harus dianjurkan untuk menghindari bahan bahan oksidan termasuk obat obat tertentu, juga harus dijelaskan mengenai resiko terjadinya hemolisis pada infeksi berulang. Selain itu juga perlu dilakukan skrining G6PD pada saudara kandung dan anggota keluarga yang lainnya.

Upaya pencegahan tersier

Upaya pencegahan tersier berupa pencegahan terjadinya komplikasi akibat paparan bahan oksidan maupun infeksi yang menimbulkan gejala klinik yang merugikan, seperti mencegah terjadinya kern ikterus pada hiperbilirubinemi neonatus yang dapat menyebabkan retardasi mental, mencegah kerusakan ginjal maupun syok akibat hemolisis akut masif maupun mencegah terjadinya juvenile katarak pada penderita defisiensi enzim G6PD.

Imunisasi

Beberapa jenis imunisasi yangdianjurkan bagi penderita defisien enzim G6PD adalah imunisasi hepatitis A dan B. Imunisasi terhadap parvovirus B19 dianjurkan karena infeksi virus ini dapat menyebabkan krisis aplastik pada penderita defisien enzim G6PD. Imunisasi terhadap pnemococcus, meningococcus dan hemophilus dalam vaksin polivalen juga direkomendasikan terutama bagi penderita yang akan menjalani operasi splenektomi.

RINGKASAN

1. G6PD merupakan satu-satunya enzim yang menyediakan NADPH yang dibutuhkan sebagai kofaktor untuk meredam senyawa oksidan (ROS) didalam sel eritrosit. Kekurangan enzim ini diturunkan secara X-linked resesif dapat menyebabkan hemolisis pada eritrosit dan manifestasi klinis lainnya terkait berkurangnya perlindungan sel terhadap senyawa oksidan.

2. Prevalensi penderita defisiensi G6PD cukup tinggi di dunia, Asia Tenggara maupun di Indonesia. Terutama di daerah endemis malaria, kelainan ini dapat memberikan keuntungan selektif bagi individu penderita untuk survive terhadap malaria.

3. Berdasarkan penelitian dan analisis molekuler selama lebih dari 40 tahun sejak defisiensi enzim G6PD diidentifikasikan, jenis varian G6PD didapatkan 442 varian dan diduga 400 juta penduduk dunia menderita kelainan ini. Berbagai jenis mutasi (varian) gen G6PD dapat mengakibatkan penurunan aktivitas G6PD. Mutasi pada exon 6 dan exon 10 dapat menyebabkan gejala klinis (anemia hemolitik) yang berat. Gejala klinis pada umumnya asimptomatik, namun bila terpapar bahan oksidan, infeksi atau makan fava beans mempunyai potensi terjadinya anemia hemolitik, ikterus neonatorum (neonatal jaundice) yang sering mengakibatkan kerusakan syaraf permanen dan dapat menyebabkan kematian. Selain itu dapat juga menimbulkan katarak, kelelahan otot dan infeksi berulang.

4. Tata laksana hanya dititikberatkan pada upaya pencegahan, sebagaimana penyakit herediter lainnya. Upaya pencegahan terbagi menjadi pencegahan primer, pencegahan sekunder maupun pencegahan tersier.

Sumber :

http://hnz11.wordpress.com/2009/05/14/obat-obatan-vs-defisiensi-g6pd/

http://laksmi.multiply.com/reviews/item/10

Misplaced Priorities

We all can recognize misplaced priorities-in other people, at least. The problem with misplaced priorities, of course, is that it's hard enough to do what you need to do, without wasting time on things that aren't going to be important in the long run. You probably have a spouse, perhaps children, parents with increasing care needs, friends at church and in your neighborhood, not to mention a room full of energetic students. There are lessons to prepare, papers to grade, meals to fix, possessions to maintain, ministry to be carried out. Some of the more pious among us might deny this, but we all have felt the frustration that Solomon well expresses in the inspired book of Ecclesiastes:"All is vanity and vexation of spirit (or striving after the wind)."
That's OK. God's providence, even His hard providence, is good, and He provides what we need in order to do what He has called us to do. But the pressure reinforces the thought that we had better not be wasting our time doing things that don't matter.
So what's the important thing? More than grades? More than efficiency? More than perfect appearances? It's been summed up in a lot of ways, but it all comes down to godliness, doesn't it? We want our children to be what they should be as well as to do what they should do. There are lots of ways to accomplish that goal, of course, but the Scripture identifies three key sources of spiritual growth in every believer. Theologians call them the "means of grace." More simply, they are avenues through which God gives us the ability to grow more like Him-to be what we should be and do what we should do:

Scripture
Paul calls the Scripture "the word of His grace" and says that it "is able to build you up" (Acts 20:32). The book is power all of its own, and we need to keep our children faces (and more importantly, their minds) in it all of the time, reading, memorizing, meditating, applying. This is spiritual calisthenics-not always fun, but always profitable. We must not produce a generation of Christians who know "what they've always been taught" but are spiritually flabby.

Prayer
The Bible calls prayer "the throne of grace" where we "find grace to help in time of need" (Heb.4:16). How real is the prayer life of your children? More to the point, how real is yours? Paul describes his companion Epaphras as "laboring fervently for you in prayers" (Col.4:12). The Greek word is agonizomai, from which we get our word agonize. When was the last time you took prayer that seriously? One of the benefits of personal disasters-terminal illness, death of a loved one, a horrific crime-is that they lead us to take prayer seriously. We need more of that.

The fellowship of believers
Paul says that our words to one another in the body "minister grace unto the hearers" (Eph.4:29). We are placed together in the body for the primary purpose of building one another up. Your children, and mine, were placed in our family because God has designed us as parents with something they needed to be more Christlike.
That's why example is so much powerful than words. And that's why our first priority must be to live godly before our charges.

Misplaced priorities. Nobody wants to waste his precious time. Even as you do less important things, focus on what matters.

Defining Christian Education

Education is the developing of character, knowledge, and skill for a desire purpose. Most educators would agree that education should prepare the student to function well throughout life.
At the core of Christianity is Christ Himself - His person (who He is) and His work (what He does). Christian education begins by introducing the student to Christ - by bringing him to realize that there is a God (Gen.1:1) to Whom he owes allegiance and obedience (Hos.13:4) and that this God has revealed Himself perfectly in His Son (Heb.1:1-3). It does this for two reasons: that he may know Him (Phil. 3:10; John 17:3) and that he may be like Him (I Cor.11:1: II Cor.3:18). Once the student is regenerate, genuine Christian education can occur.
Just as Christ is the perfect revealing of God, so the Scripture is the perfect revealing of Christ (John 5:39). Christian education must recognize the Scripture as its primary written text. The student will learn theological doctrine from the Scripture, but Christian education depends on the Word for more than that. Since God is the Creator (John 1:3) and since He is truth (Ex.34:6; John 14:6), then all that is true comes from Him, and all subjects must be taught from His perspective. The Bible was not intended to be a science textbook, and a chemistry course will include large amounts of material that is not in the Scripture. But the Bible is accurate whenever it speaks to any subject, and perhaps more importantly, it sets forth a worldview - creationist and providentialist - that must inform and direct the study of every subject.
Education includes development of character as well as transfer of information. The character goals of Christian education will be Christian in the narrowest sense: they will imitate the character of Christ as revealed in the Scripture. Every part of the student's school day will reflect the purposeful discipline that is necessary to the development of Christ-likeness.

What, then, will the product of truly Christian education look like?
He is a born-again Christian who is purposefully pursuing Christ-likeness in himself and others. Accomplishing of the will of God is his primary purpose for living. As his God-given talents and abilities allow, he is a critical thinker. He enjoys learning and is devoted to continuing his education throughout his life because it leads him to glorify God. And because he has the intellectual and character-based tools, he will be good at whatever God has called him to do.

Pointing Boys Toward Manhood

Good men do not appear by accident. With dilligent prayer and careful discipleship, you can guide your son to manhood.
But nobody grows up well in an environment of inattention or diminution. To become decent and successful adults, children need direction.
A number of organizations, both secular and religious, have noted our culture's relative inattention to the importance of strong males in both home and society, almost certainly as the result of feminism's increasing reach into the primary cultural institution. Christian educators, including homeschooling parents, would do well to give attention to the effect they can have on their male students in directing them toward biblical manhood.

Biblical Data

What is biblical manhood like?
The Bible answer that question in two ways: by precept, or direct statement, and by example.
Scripture is filled with examples of godly men, from Job to Moses to David to Paul (and of course to Jesus Himself, who though fully God is fully man as well).
What are some of main ideas? What characteristics do we want to nurture in the lives of young men? What follows is a sample, but these are perhaps the most heavily emphasized in the Scripture.

Leadership Qualities

Most people are not the king, of course; there can be only one king in a nation because somebody has to pay the taxes. But God has ordained three institutions (home, state, church), and in two of them the Scripture directs that the leadership be male. The great majority of men, then, will be in some kind of leadership role, and we err if we do not prepare boys for that future role.
What qualities does a good leader need?

~ Humility
~ Responsibility / Dilligence
~ Self - control
~ Love
~ Attentiveness
~ Empathy
~ Courage
Christlikeness
~ Obedience
~ Devotion to the Father
~ Goodness
~ Knowledge
~ Endurance
Application
~ Responsibility
~ Interaction
~ Challenge
~ Clear direction

Good men do not appear by accident. They are the product of the work of the Holy Spirit, the study of Scripture, diligent prayer, and careful discipleship. In God's providence, you have been placed in a discipleship role for your sons. Disciple on purpose.

(taken from homeshcool helper BJU)

Top Ten Ways to Raise Emotionally Intelligent Kids

Having a high level of emotional intelligence in your children is the best way to ensure that they live a happy, successful and responsible life as an adult. Here are ten ways to help your kids attain a high degree of emotional intelligence:

1. Model emotional intelligence yourself.
Yes, your kids are watching very closely. They see how you respond to frustration, they see how resilient you are and they see whether you're aware of your own feelings and the feelings of others.

2. Be willing to say "no" to your kids.
There's a lot of stuff out there for kids, and your kids will ask for a lot of it. Saying no will give your kids an opportunity to deal with disappointment and to learn impulse control. To a certain degree, your job as a parent is to allow your kids to be frustrated and to work through it. Kids who always get what they want typically aren't very happy.

3. Be aware of your parental "hotspots."
Know what your issues are -- what makes you come unglued, and what's this really about? Is it not being in control? Not being respected? Underneath these issues lies a fear about something. Get to know what your fear is, so you're less likely to come unglued when you're with your kids. Knowing your issues doesn't make them go away -- it just makes it easier to plan for and to deal with.

4. Practice and hone your skills at being non-judgmental.
Start labeling feelings and avoid name-calling. Say, "He seems angry," rather than "What a jerk." When your kids are whiny or crying, saying things like, "You seem sad," will always be better than just asking them to stop. Depriving kids of the feelings they're experiencing will only drive them underground and make them stronger.

5. Start coaching your kids.
When kids are beyond the toddler years, you can start coaching them to help them to be more responsible. Instead of "Get your hat and gloves," you can ask, "What do you need to be ready for school?" Constantly telling your kids what to do does not help them to develop confidence and responsibility.

6. Always be willing to be part of the problem.
See yourself as having something to do with every problem that comes along. Most problems in families get bigger when parents respond to them in a way that exacerbates the problem. If your child makes a mistake, remember how crucial it is for you to have a calm, reasoned response.

7. Get your kids involved in household duties at an early age.
Research suggests that kids who are involved in household chores from an early age tend to be happier and more successful. Why? From an early age, they're made to feel they are an important part of the family. Kids want to belong and to feel like they're valuable.

8. Limit your kids access to mass media mania.
Young kids need to play, not spend time in front of a screen. To develop creativity and problem-solving skills, allow your kids time to use free play. Much of the mass media market can teach your kids about consumerism, sarcasm and violence. What your kids learn from you and from free play with others will provide the seeds for future emotional intelligence.

9. Talk about feelings as a family.
State your emotional goals as a family. These might be no yelling, no name-calling, be respectful at all times, etc. Families that talk about their goals are more likely to be aware of them and to achieve them. As the parent, you then have to "walk the talk."

10. See your kids as wonderful.
There is no greater way to create emotional intelligence in your child than to see them as wonderful and capable. One law of the universe is, "What you think about expands." If you see your child and think about them as wonderful, you'll get a lot of "wonderful." If you think about your child as a problem, you'll get a lot of problems.

Having a high IQ is nice, but having a high "EQ" is even better. Make these 10 ideas daily habits and you'll give your kids the best chance possible to be happy, productive and responsible adults.

© Mark Brandenburg

To Help the Fatherless

We all know about the rapid increase in crime, drug use, gangs, homicides, school failure and dropouts, depression, suicides, and poverty among teens. But what is not so well known is one major cause for such problems: fatherless homes.

What the Bible Says About the Fatherless

If we desire to be Christ-like, we will have the same concern for the fatherless that God has for them. He is a father and a helper (Ps. 10: 14) to them. He hear their cries (Exod.22: 23-24; Isa.10:1-3;Mal.3:5). God warns us not to defraud (Prov.23:10), afflict (Exod.22:22), or do violence (Jer.22:3) to them. In the New Testament we are instructted to visit the fatherless and widows to prove that our religion is genuine (James 1:27). We must be patient and gentle, not judgmental, always ready to teach and help them, especially concering spiritual matters (II Tim.2:24-26).

What We Should Know

Avoid being alone with the opposite sex, especially teens, for extended periods. Husband-and-wife teams are ideal to work with fatherless children.

Encourage the child to discuss with his mother any inappropriate or unusual behavior, situations, or remarks he tells you about.

What We Can Do

Helpers, including teachers, need to know how to build and maintain relationships with fatherless children and their mother:

• Fatherless children need stability in relationship, so think in terms of working with them over extended periods.
• Be as positive as possible and encourage with praise and "good words fitly spoken." ~ Use public prise and private reprimand. Let the mother do most of the correction.
• Look for opportunities to give spiritual help.
• Participate with them in social activities,

(Taken from newsletter BJUP by Walter G.Fremont, Ed.D.)

The Power Of Motherhood

Mothering in today's world is no easy task. Culture around us seeks to deceive mothers into thinking that what they are doing does not matter in the present or the future. How, as Christian mothers are we called to respond to this deception? We cannot influence generations if we are gullible in our thinking and weak in our walk with the Lord. We must strengthen our minds daily with the Word and be able to discern what righteous thinking is in an evil, anti-family world.

Satan knows the power motherhood holds. He would like us to perceive it as lowly, despised, wasteful and even burdensome as is so commonly believed today. It is evidenced in broken homes and neglected children---a result of generational breakdown and sin. Lies that are common for mothers today are: "It's too hard, I can't handle it." or "I'm wasting my time, there are 'greater' things I can do with my life." Dear mothers, there is no greater calling than right where our gracious Lord has so sovereignly placed you, to raise precious souls for the King of Kings. Souls are eternal, and earthly, worldy pursuits are not. Let us always keep that perspective---with one eye on the present and another on the eternal.

So therefore His heart must be our heart. We want to walk in the full anointing, joy and glory of motherhood that he has purposed for us. We must free ourselves of the bondages that hinder motherhood. That means getting rid of all the lies, that means not accepting the worlds way of parenting, that means taking up our cross and dying to self. We must immerse ourselves in our role and delight in it!

(Taken from The High Calling by Ladylydiaspeaks)

Comfort Place

Almost anyone of us has a place to live and we called it a house. A house is a place, which is not only for living, shelter from sunlight and rain, but a house is also a place where everyone lives inside has their own activities, doing their hobbies, relaxing, and many things such as loving, caring, supporting and respecting each other are the most important thing. When we go home after working whole day, when we want to enjoy our “favorite place” to release stress, relax for a moment with our beloved person, those kind of feelings are gone.

During our vacation in some place out of city, there is a moment we miss our “favorite place”, which is our home, although the place was so fine. And when we come back home, we are very pleased to be there in time after being in another place.

Why this can be happened?

Naturally, people like regular activities, with other words that people don’t like a change.
Regular activities may make us comfortable with that. When we get use to do some activities regularly, once we don’t do that due some reason, we would have “loosing” feeling, something we missed in our life. For example, we have been living at a house since 6 years ago. Once upon time, we have to move to another house. For sure, it feels so hard for us to leave the house.

There are many things to a consideration to make our selves feel at home, such as whom we live with and how good the relationship is within. In fact, many people still consider their home is not as their “favorite place” to stay.
Probably, this could happened because of careless from each other between member of family in their house.

No matter the house is luxurious or in contrary, convenience in our house doesn’t depend on that matter. But its individually matter. We are talking here about relationship. If our convenience at home depend on our selves, why we can’t start with our selves first.

Let’s share our love, peaceful, care and respect to anyone around us wherever we are belong to. Thus, they will feel secure and comfort stay at home.